276 IMPAIRED NEONATAL PARATHYROID FUNCTION AND MATERNAL HYPERPARATHYROIDISM

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Neonatal hypocalcaemia associated with maternal hyperparathyroidism

A 32-day-old male infant had hypocalcaemic convulsions associated with asymptomatic maternal hyperparathyroidism. Very low total and ionised serum calcium, increased serum phosphate, and normal serum parathyroid hormone (PTH) and 25-hydroxycholecalciferol (25-OHD3) concentrations were found at admission. After treatment with calcium and vitamin D, serum PTH and 25-OHD3 concentrations increased ...

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Transient neonatal hyperparathyroidism secondary to maternal pseudohypoparathyroidism.

A neonate was found to have normocalcaemic hyperparathyroidism with bone disease. The plasma parathyroid hormone concentration returned to normal by 4 weeks, and healing of the bone lesions was evident by age 5 months. The mother proved to have pseudohypoparathyroidism, previously unsuspected.

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Intraoperative parathyroid hormone monitoring in neonatal severe primary hyperparathyroidism.

Neonatal severe primary hyperparathyroidism presents in the first days of life with severe life-threatening hypercalcemia. It is associated with an inactivating homozygous mutation of the calcium sensing receptor gene. Total parathyroidectomy is the treatment of choice, so the surgeon must identify all the parathyroid tissue, including supernumerary and ectopic glands. We present the case of an...

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Cystic multiglandular maternal hyperparathyroidism diagnosed by neonatal hypocalcemic seizures

A 7-day-old male infant born to a healthy 33-year-old female at 37 weeks of gestation was brought to the local emergency department (ED) with sudden-onset tonic-clonic seizures. Laboratory testing revealed extreme hypocalcemia (ionized calcium of 3.2 mg/dl) and undetectable parathyroid hormone (PTH <10 pg/ml). Concomitant evaluation of the mother revealed both elevated ionized calcium (5.9 mg/d...

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Neonatal Seizure as a Manifestation of Unrecognized Maternal Hyperparathyroidism

Maternal hypercalcemia suppresses parathyroid activity in the fetus resulting in impaired parathyroid responsiveness to hypocalcemia after birth. Resultant hypocalcemia may be severe and prolonged and rarely may lead to convulsions. Here, we present a newborn infant admitted to the pediatric emergency department at age two weeks with recurrent tonic convulsions due to asymptomatic maternal hype...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1978

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-197804001-00281